Satan is the lord of hell and the main villain in the Warner short Hot Bothered and Bedeviled. Due to his phylosopical interpretation, the episode was almost banned. He sports bloody red skin, yellow eyes, and burgundy legs. He also owns a dog named Cerberus. The Warners first break inside his realm with a mallet, thinking it's Five Flags to Flushing. However, the Devil informs them that they are in Hell. Wakko runs to a snowy landscape, grabs a snowball, and returns with it, placing it on the floor. He says, "They were right. It didn't have a chance!", referencing A Snowball's Chance in Hell. Hades attempts to throw them in a room with a whiny protestor from the 60s, singing, " Oh, I hate the government, more than you and me, the government stole my goldfish, and unplugged my TV". However, used in episodes 4 and 48, when he throws the Warners in, he gets thrown in instead.
Hades then tries to harm the Warners with Cerberus, his dog. However, Dot shows him her pet, making him flee. Hades grows large, and Wakko makes his neck stretch, pretending to be a giraffe. Hades engages in a competition with Wakko to see who can grow larger. Eventually, he gets his horns stuck in the ceiling and says, "Stupid horns. I knew I should've gotten them trimmed".
Later, the Warners are on a boat with the Grim Reaper, singing a song about Purgatory. When they leave the boat, he storms in their way, telling them that this is the end. Yakko asks his siblings if they have an idea, but neither has one. Yakko then freezes the entire place by saying, "Freeze Frame!". Hades gets angry and kicks them out, where they land in Heaven. As the Saint is about to introduce his name, Dot interrupts him by saying, "Excuse me, but would you be a doll and hold that thought?".
Hades appears in Tiny Toons Night Ghoulery, where Plucky is Montana Max's lawyer. However, it appears only to be Babs Bunny.